Ionic-Liquid-Supported Synthesis of Amines and Derivatives
نویسندگان
چکیده
Amine precursors such as NH-Boc (5) and NH-formyl (6) protected glycines were grafted by esterification on the hy-droxylated arms of 1-(2-hydroxyethyl)-3-methylimidazolium hexafluorophosphates 4h or tetrafluoroborates 4t. The Boc cleav-age was then realized at room temperature by successively treating acetonitrile solutions of the carbamates 7h or 7t with methanol and acetyl chloride (2 equivalents each). Interestingly, the hydrochlo-rides were converted to the corresponding amines 9h or 9t, respectively , during the removal of the solvent. Ugi reaction of the ionic liquid-grafted amine 9bt with phthalaldehydic acid and tert-butylisonitrile, followed by cleavage, furnished the phthalimidine 12.
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